Aquaporin-4 water channel expression in human vasogenic brain oedema
نویسندگان
چکیده
منابع مشابه
Symmetrical 'vasogenic' brain oedema.
Low attenuation of the cerebral white matter occurs with oedema and demyelination. When unilateral or asymmetrical it is usually due to a tumour, granuloma or abscess. The nidus responsible for the vasogenic oedema can be demonstrated after contrast enhancement. Bilateral demyelination occurs especially with viral infections such as herpes simplex encephalitis and progressive multifocal leukoen...
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Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system. Expression is particularly high around areas in contact with cerebrospinal fluid, suggesting that AQP4 plays a role in fluid exchange between the cerebrospinal fluid compartments and the brain. Despite its significant role in the brain, the overall spatial and region-specific d...
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The pattern of aquaporin-1 water channel protein (AQP1) expression in the human kidney was analyzed by immunocytochemistry using semi-thin and optimized high-resolution immunoelectron microscopy based on freeze-substituted and Lowicryl HM20 embedded tissue. In addition, in situ hybridization was used to determine AQP1 mRNA distribution. Immunoblots revealed a 28-kd band and a 35- to 45-kd band ...
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This paper investigates the mechanism of water transportation through aquaporin-4(AQP4) of ratbrain cells by means of molecular dynamics simulation with CHARMM software. The AQP4 wasembedded into a bilayer made of Dimystroilphosphatylcholine (DMPC). The results illustrate thatwater molecules move through AQP4's channel with change of orientation of oxygen of eachwater molecule.
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In this study, we have investigated the expression of aquaporin 4 during blood-brain barrier development in the optic tectum of chick embryos and newly hatched chicks, by means of western-blot, reverse transcriptase-polymerase chain reaction, immunohistochemistry, and freeze-fracture and high-resolution immunogold electron microscopy. In the optic tecta of day-14 embryos, western blot analysis ...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2002
ISSN: 0021-8782,1469-7580
DOI: 10.1046/j.1469-7580.2002.00047_2.x